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Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects
The central terminals of primary afferent fibers experience depolarization upon activation of GABA(A) receptors (GABA(A)R) because their intracellular chloride concentration is maintained above electrochemical equilibrium. Primary afferent depolarization (PAD) normally mediates inhibition via sodium...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105942/ https://www.ncbi.nlm.nih.gov/pubmed/27835641 http://dx.doi.org/10.1371/journal.pcbi.1005215 |