Regulation of mTORC1 by lysosomal calcium and calmodulin

Blockade of lysosomal calcium release due to lysosomal lipid accumulation has been shown to inhibit mTORC1 signaling. However, the mechanism by which lysosomal calcium regulates mTORC1 has remained undefined. Herein we report that proper lysosomal calcium release through the calcium channel TRPML1 i...

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Detalles Bibliográficos
Autores principales: Li, Ruo-Jing, Xu, Jing, Fu, Chenglai, Zhang, Jing, Zheng, Yujun George, Jia, Hao, Liu, Jun O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106211/
https://www.ncbi.nlm.nih.gov/pubmed/27787197
http://dx.doi.org/10.7554/eLife.19360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106211/
https://www.ncbi.nlm.nih.gov/pubmed/27787197
http://dx.doi.org/10.7554/eLife.19360

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