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Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats

Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1) to modulate DCM and its related mechanisms. Twenty-four male Wistar rats were...

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Detalles Bibliográficos
Autores principales: Wang, Cheng Yu, Li, Xiang Dan, Hao, Zhi Hong, Xu, Dongyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106395/
https://www.ncbi.nlm.nih.gov/pubmed/27847438
http://dx.doi.org/10.4196/kjpp.2016.20.6.613