Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(−/−) Hematopoietic Stem and Progenitor Cells

Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA crosslink lesion repair. In bone marrow HSPCs, unresolved stress confers p53-dependent apoptosis and progressive cell attriti...

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Detalles Bibliográficos
Autores principales: Yoon, Young me, Storm, Kelsie J., Kamimae-Lanning, Ashley N., Goloviznina, Natalya A., Kurre, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106485/
https://www.ncbi.nlm.nih.gov/pubmed/27720904
http://dx.doi.org/10.1016/j.stemcr.2016.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106485/
https://www.ncbi.nlm.nih.gov/pubmed/27720904
http://dx.doi.org/10.1016/j.stemcr.2016.09.005

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