Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant

In Caenorhabditis elegans, cellular proteostasis is likely essential for longevity. Autophagy has been shown to be essential for lifespan extension of daf-2 insulin/IGF mutants. Therefore, it can be hypothesized that daf-2 mutants achieve this phenotype by increasing protein turnover. However, such...

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Detalles Bibliográficos
Autores principales: Depuydt, Geert, Shanmugam, Nilesh, Rasulova, Madina, Dhondt, Ineke, Braeckman, Bart P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106850/
https://www.ncbi.nlm.nih.gov/pubmed/26865495
http://dx.doi.org/10.1093/gerona/glv221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106850/
https://www.ncbi.nlm.nih.gov/pubmed/26865495
http://dx.doi.org/10.1093/gerona/glv221

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