Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

BACKGROUND: Because of the vulnerability and frailty of elderly adults, clinical drug development has traditionally been biased towards young and middle-aged adults. Recent efforts have begun to incorporate data from paediatric investigations. Nevertheless, the elderly often remain underrepresented...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlender, Jan-Frederik, Meyer, Michaela, Thelen, Kirstin, Krauss, Markus, Willmann, Stefan, Eissing, Thomas, Jaehde, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107207/
https://www.ncbi.nlm.nih.gov/pubmed/27351180
http://dx.doi.org/10.1007/s40262-016-0422-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107207/
https://www.ncbi.nlm.nih.gov/pubmed/27351180
http://dx.doi.org/10.1007/s40262-016-0422-3

Ejemplares similares