Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C

Human cystatin C (hCC) is a small cysteine protease inhibitor whose oligomerization by propagated domain swapping is linked to certain neurological disorders. One of the ways to prevent hCC dimerization and fibrillogenesis is to enable its interaction with a proper antibody. Herein, the sites of int...

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Detalles Bibliográficos
Autores principales: Prądzińska, Martyna, Behrendt, Izabela, Astorga-Wells, Juan, Manoilov, Aleksandr, Zubarev, Roman A., Kołodziejczyk, Aleksandra S., Rodziewicz-Motowidło, Sylwia, Czaplewska, Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107209/
https://www.ncbi.nlm.nih.gov/pubmed/27573935
http://dx.doi.org/10.1007/s00726-016-2316-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107209/
https://www.ncbi.nlm.nih.gov/pubmed/27573935
http://dx.doi.org/10.1007/s00726-016-2316-y

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