Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy

AIM: To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma (SESCC) on Narrow Band Imaging combined with magnifying endoscopy (NBI-ME). METHODS: This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with p...

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Autores principales: Dobashi, Akira, Goda, Kenichi, Yoshimura, Noboru, Ohya, Tomohiko R, Kato, Masayuki, Sumiyama, Kazuki, Matsushima, Masato, Hirooka, Shinichi, Ikegami, Masahiro, Tajiri, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107600/
https://www.ncbi.nlm.nih.gov/pubmed/27895406
http://dx.doi.org/10.3748/wjg.v22.i41.9196
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author Dobashi, Akira
Goda, Kenichi
Yoshimura, Noboru
Ohya, Tomohiko R
Kato, Masayuki
Sumiyama, Kazuki
Matsushima, Masato
Hirooka, Shinichi
Ikegami, Masahiro
Tajiri, Hisao
author_facet Dobashi, Akira
Goda, Kenichi
Yoshimura, Noboru
Ohya, Tomohiko R
Kato, Masayuki
Sumiyama, Kazuki
Matsushima, Masato
Hirooka, Shinichi
Ikegami, Masahiro
Tajiri, Hisao
author_sort Dobashi, Akira
collection PubMed
description AIM: To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma (SESCC) on Narrow Band Imaging combined with magnifying endoscopy (NBI-ME). METHODS: This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopists detected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: “intervascular background coloration”; “proliferation of intrapapillary capillary loops (IPCL)”; and “dilation”, “tortuosity”, “change in caliber”, and “various shapes (VS)” of IPCLs (i.e., Inoue’s tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue’s criteria. RESULTS: Fifty-four lesions (65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC (P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue’s tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue’s tetrad criteria, respectively. CONCLUSION: The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBI-ME.
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spelling pubmed-51076002016-11-28 Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy Dobashi, Akira Goda, Kenichi Yoshimura, Noboru Ohya, Tomohiko R Kato, Masayuki Sumiyama, Kazuki Matsushima, Masato Hirooka, Shinichi Ikegami, Masahiro Tajiri, Hisao World J Gastroenterol Retrospective Study AIM: To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma (SESCC) on Narrow Band Imaging combined with magnifying endoscopy (NBI-ME). METHODS: This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopists detected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: “intervascular background coloration”; “proliferation of intrapapillary capillary loops (IPCL)”; and “dilation”, “tortuosity”, “change in caliber”, and “various shapes (VS)” of IPCLs (i.e., Inoue’s tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue’s criteria. RESULTS: Fifty-four lesions (65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC (P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue’s tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue’s tetrad criteria, respectively. CONCLUSION: The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBI-ME. Baishideng Publishing Group Inc 2016-11-07 2016-11-07 /pmc/articles/PMC5107600/ /pubmed/27895406 http://dx.doi.org/10.3748/wjg.v22.i41.9196 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Dobashi, Akira
Goda, Kenichi
Yoshimura, Noboru
Ohya, Tomohiko R
Kato, Masayuki
Sumiyama, Kazuki
Matsushima, Masato
Hirooka, Shinichi
Ikegami, Masahiro
Tajiri, Hisao
Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy
title Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy
title_full Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy
title_fullStr Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy
title_full_unstemmed Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy
title_short Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy
title_sort simplified criteria for diagnosing superficial esophageal squamous neoplasms using narrow band imaging magnifying endoscopy
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107600/
https://www.ncbi.nlm.nih.gov/pubmed/27895406
http://dx.doi.org/10.3748/wjg.v22.i41.9196
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