Cargando…

11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes

Glucocorticoids are used to treat a number of human diseases but often lead to insulin resistance and metabolic syndrome. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that catalyzes the intracellular conversion of cortisone to physiologically active cortisol. Despite the known...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Kesong, Pan, Yong, Li, Jieli, Khan, Zia, Fan, Mendi, Yin, Haimin, Tong, Chao, Zhao, Yunjie, Liang, Guang, Zheng, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107914/ https://www.ncbi.nlm.nih.gov/pubmed/27841334 http://dx.doi.org/10.1038/srep37160

Ejemplares similares

Variants of 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 in Chinese obese adolescents
por: Chun, Zou Chao
Publicado: (2013)

Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders
por: Dodd, Seetal, et al.
Publicado: (2022)

Regulation of Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) by CCAAT/Enhancer-Binding Protein (C/EBP) β Isoforms, LIP and LAP
por: Esteves, Cristina L., et al.
Publicado: (2012)

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms
por: Harno, Erika, et al.
Publicado: (2013)

S100A16-induced adipogenesis is associated with up-regulation of 11 β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
por: Zhang, Rihua, et al.
Publicado: (2019)

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
por: Webster, Scott P, et al.
Publicado: (2017)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
por: Kosicka, Katarzyna, et al.
Publicado: (2016)

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
por: Nakata, Takaya, et al.
Publicado: (2016)

HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta
por: Dickson, Alison, et al.
Publicado: (2023)

11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
por: Bailey, Matthew A.
Publicado: (2017)

11β-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity
por: Zou, Chunpeng, et al.
Publicado: (2017)

Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)
por: Spadaro, Alessandro, et al.
Publicado: (2012)

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene
por: Pullen, Timothy J., et al.
Publicado: (2017)

Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases
por: Markey, Keira A, et al.
Publicado: (2016)

Cortisol, Hypertension and Obesity: The Role of 11β-Hydroxysteroid Dehydrogenase
por: Stewart, Paul M
Publicado: (1998)

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis
por: Lee, Noo Ri, et al.
Publicado: (2020)

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
por: Michailidou, Zoi, et al.
Publicado: (2012)

Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2
por: Thompson, George R, et al.
Publicado: (2019)

Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2
por: Wang, Yiyan, et al.
Publicado: (2019)

The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
por: Nakata, Takaya, et al.
Publicado: (2016)

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
por: Morgan, Stuart A., et al.
Publicado: (2009)

Population Target-Mediated Pharmacokinetic/Pharmacodynamic Modeling to Evaluate SPI-62 Exposure and Hepatic 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition in Healthy Adults
por: Wu, Nan, et al.
Publicado: (2023)

PMON72 The "RESCUE" Trial: 11beta-Hydroxysteroid Dehydrogenase Type 1 (HSD-1) Inhibition for ACTH-Dependent Cushing's Syndrome
por: Czerwiec, Frank S, et al.
Publicado: (2022)

Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans
por: Stimson, Roland H., et al.
Publicado: (2009)

Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
por: Su, Xiangdong, et al.
Publicado: (2011)

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation
por: Chapman, Karen E., et al.
Publicado: (2013)

Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors
por: Su, Xiangdong, et al.
Publicado: (2012)

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet
por: Johnson, Jethro S, et al.
Publicado: (2016)

Development and structure–activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors
por: Deng, Xu, et al.
Publicado: (2022)

11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases
por: Kupczyk, Daria, et al.
Publicado: (2022)

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation
por: Hadoke, Patrick W. F., et al.
Publicado: (2013)

Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2
por: Li, Linxi, et al.
Publicado: (2015)

Changes in 11β-Hydroxysteroid Dehydrogenase and Glucocorticoid Receptor Expression in Kawasaki Disease
por: Wang, Juanli, et al.
Publicado: (2017)

11β-Hydroxysteroid dehydrogenase type 1 amplifies inflammation in LPS-induced THP-1 cells
por: Luo, Lingli, et al.
Publicado: (2023)

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates
por: Bird, A Daniel, et al.
Publicado: (2017)

Structural Basis for Species Specific Inhibition of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Computational Study and Biological Validation
por: Klein, Tobias, et al.
Publicado: (2011)

A novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
por: Bujalska, I J, et al.
Publicado: (2008)

Tissue-Specific Increases in 11β-Hydroxysteroid Dehydrogenase Type 1 in Normal Weight Postmenopausal Women
por: Andersson, Therése, et al.
Publicado: (2009)

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis
por: Kipari, Tiina, et al.
Publicado: (2013)

11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation
por: Verma, Manu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0gos2a7seq003p3lvgkdo8oolf