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Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin

BACKGROUND: The antimalarial activity of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a naturally occurring naphthoquinone widely distributed in the Plumbaginaceae family has previously been demonstrated in vitro (good activity) and in vivo (weak activity). The aim of the study was to investig...

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Detalles Bibliográficos
Autores principales: Sumsakul, Wiriyaporn, Plengsuriyakarn, Tullayakorn, Na-Bangchang, Kesara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108082/
https://www.ncbi.nlm.nih.gov/pubmed/27839515
http://dx.doi.org/10.1186/s40360-016-0094-5