Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

Type 2 diabetes is a chronic metabolic disorder, where failure to maintain normal glucose homoeostasis is associated with, and exacerbated by, obesity and the concomitant-elevated free fatty acid concentrations typically found in these patients. Hyperglycaemia and hyperlipidaemia together contribute...

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Detalles Bibliográficos
Autores principales: Bagnati, Marta, Ogunkolade, Babatunji W, Marshall, Catriona, Tucci, Carmen, Hanna, Katie, Jones, Tania A, Bugliani, Marco, Nedjai, Belinda, Caton, Paul W, Kieswich, Julius, Yaqoob, Muhammed M, Ball, Graham R, Marchetti, Piero, Hitman, Graham A, Turner, Mark D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108311/
https://www.ncbi.nlm.nih.gov/pubmed/27512950
http://dx.doi.org/10.1038/cddis.2016.203

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