TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome

Understanding the mechanisms that contribute to secondary cone photoreceptor loss in retinitis pigmentosa (RP) is critical to devise strategies to prolong vision in this neurodegenerative disease. We previously showed that constitutive activation of the mammalian target of rapamycin complex 1 (mTORC...

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Detalles Bibliográficos
Autores principales: Venkatesh, A, Ma, S, Punzo, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108335/
https://www.ncbi.nlm.nih.gov/pubmed/27362797
http://dx.doi.org/10.1038/cddis.2016.182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108335/
https://www.ncbi.nlm.nih.gov/pubmed/27362797
http://dx.doi.org/10.1038/cddis.2016.182

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