Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis

We previously reported that renal clear cell carcinoma cells (RCC) express both tumor necrosis factor receptor (TNFR)-1 and -2, but that, in organ culture, a TNF mutein that only engages TNFR1, but not TNFR2, causes extensive cell death. Some RCC died by apoptosis based on detection of cleaved caspa...

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Detalles Bibliográficos
Autores principales: Al-Lamki, R S, Lu, W, Manalo, P, Wang, J, Warren, A Y, Tolkovsky, A M, Pober, J S, Bradley, J R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108336/
https://www.ncbi.nlm.nih.gov/pubmed/27362805
http://dx.doi.org/10.1038/cddis.2016.184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108336/
https://www.ncbi.nlm.nih.gov/pubmed/27362805
http://dx.doi.org/10.1038/cddis.2016.184

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