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Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase
Fructose-1,6-bisphosphatase (FBPase) is a key regulator of gluconeogenesis and a potential drug target for type 2 diabetes. FBPase is a homotetramer of 222 symmetry with a major and a minor dimer interface. The dimers connected via the minor interface can rotate with respect to each other, leading t...
Autores principales: | Ruf, Armin, Tetaz, Tim, Schott, Brigitte, Joseph, Catherine, Rudolph, Markus G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108348/ https://www.ncbi.nlm.nih.gov/pubmed/27841754 http://dx.doi.org/10.1107/S2059798316016715 |
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