Nuclear Thioredoxin‐1 Overexpression Attenuates Alcohol‐Mediated Nrf2 Signaling and Lung Fibrosis

BACKGROUND: Alcohol abuse, which impairs antioxidant defenses and promotes acute lung injury, increases Nrf2 nuclear translocation but nevertheless inhibits its activation of the antioxidant response element (ARE). Thioredoxin‐1 (Trx1) is required for optimal Nrf2 binding and activation of the ARE,...

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Detalles Bibliográficos
Autores principales: Sueblinvong, Viranuj, Mills, Stephen T., Neujahr, David C., Go, Young‐Mi, Jones, Dean P., Guidot, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cell and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108489/
https://www.ncbi.nlm.nih.gov/pubmed/27436123
http://dx.doi.org/10.1111/acer.13148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108489/
https://www.ncbi.nlm.nih.gov/pubmed/27436123
http://dx.doi.org/10.1111/acer.13148

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