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Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats
The aim of the study was to improve the oral absorption of the compound 25-OCH(3)-PPD with poor hydrophilicity and lipophilicity. 25-OCH(3)-PPD-phospholipid complex was prepared by solvent evaporation, then characterized by differential scanning calorimetry, scanning electron microscopy, and infrare...
Autores principales: | Zhang, Xiangrong, Zhang, Yi, Guo, Shuang, Bai, Feifei, Wu, Tong, Zhao, Yuqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108498/ https://www.ncbi.nlm.nih.gov/pubmed/27877020 http://dx.doi.org/10.2147/DDDT.S114374 |
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