Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons

Mutations in the MECP2 gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous studies have shown that altered MeCP2 levels result in aberrant neurite outgrowth and glutamatergic synapse formation. However, causal molecular mechanisms are not well understood since MeCP2 is known to...

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Detalles Bibliográficos
Autores principales: Sampathkumar, Charanya, Wu, Yuan-Ju, Vadhvani, Mayur, Trimbuch, Thorsten, Eickholt, Britta, Rosenmund, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108590/
https://www.ncbi.nlm.nih.gov/pubmed/27782879
http://dx.doi.org/10.7554/eLife.19374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108590/
https://www.ncbi.nlm.nih.gov/pubmed/27782879
http://dx.doi.org/10.7554/eLife.19374

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