Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome

The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3, the murine homologue of human SPINK1, die perinatally due to massive...

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Detalles Bibliográficos
Autores principales: Sakata, Kazuya, Araki, Kimi, Nakano, Hiroyasu, Nishina, Takashi, Komazawa-Sakon, Sachiko, Murai, Shin, Lee, Grace E., Hashimoto, Daisuke, Suzuki, Chigure, Uchiyama, Yasuo, Notohara, Kenji, Gukovskaya, Anna S., Gukovsky, Ilya, Yamamura, Ken-ichi, Baba, Hideo, Ohmuraya, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109027/
https://www.ncbi.nlm.nih.gov/pubmed/27845447
http://dx.doi.org/10.1038/srep37200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109027/
https://www.ncbi.nlm.nih.gov/pubmed/27845447
http://dx.doi.org/10.1038/srep37200

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