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Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3, the murine homologue of human SPINK1, die perinatally due to massive...
Autores principales: | Sakata, Kazuya, Araki, Kimi, Nakano, Hiroyasu, Nishina, Takashi, Komazawa-Sakon, Sachiko, Murai, Shin, Lee, Grace E., Hashimoto, Daisuke, Suzuki, Chigure, Uchiyama, Yasuo, Notohara, Kenji, Gukovskaya, Anna S., Gukovsky, Ilya, Yamamura, Ken-ichi, Baba, Hideo, Ohmuraya, Masaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109027/ https://www.ncbi.nlm.nih.gov/pubmed/27845447 http://dx.doi.org/10.1038/srep37200 |
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