Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration

Axonal degeneration is a key initiating event in many neurological diseases. Focal lesions to axons result in a rapid disintegration of the perilesional axon by acute axonal degeneration (AAD) within several hours. However, the underlying molecular mechanisms of AAD are only incompletely understood....

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Detalles Bibliográficos
Autores principales: Zhang, Jian-Nan, Michel, Uwe, Lenz, Christof, Friedel, Caroline C., Köster, Sarah, d’Hedouville, Zara, Tönges, Lars, Urlaub, Henning, Bähr, Mathias, Lingor, Paul, Koch, Jan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109185/
https://www.ncbi.nlm.nih.gov/pubmed/27845394
http://dx.doi.org/10.1038/srep37050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109185/
https://www.ncbi.nlm.nih.gov/pubmed/27845394
http://dx.doi.org/10.1038/srep37050

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