Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue

Chikungunya virus (CHIKV), genus Alphavirus, family Togaviridae, has a positive-stand RNA genome approximately 12 kb in length. In infected cells, the genome is translated into non-structural polyprotein P1234, an inactive precursor of the viral replicase, which is activated by cleavages carried out...

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Detalles Bibliográficos
Autores principales: Rausalu, Kai, Utt, Age, Quirin, Tania, Varghese, Finny S., Žusinaite, Eva, Das, Pratyush Kumar, Ahola, Tero, Merits, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109220/
https://www.ncbi.nlm.nih.gov/pubmed/27845418
http://dx.doi.org/10.1038/srep37124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109220/
https://www.ncbi.nlm.nih.gov/pubmed/27845418
http://dx.doi.org/10.1038/srep37124

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