Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

Hepatocellular carcinoma (HCC) is refractory to chemotherapies, necessitating novel effective agents. The lysosome inhibitor Bafilomycin A1 (BafA1) at high concentrations displays cytotoxicity in a variety of cancers. Here we show that BafA1 at nanomolar concentrations suppresses HCC cell growth in...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Yumei, Jiang, Ke, Liu, Peng, Zhang, Xianbin, Dong, Xin, Gao, Jingchun, Liu, Quentin, Barr, Martin P., Zhang, Quan, Hou, Xiukun, Meng, Songshu, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109251/
https://www.ncbi.nlm.nih.gov/pubmed/27845389
http://dx.doi.org/10.1038/srep37052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109251/
https://www.ncbi.nlm.nih.gov/pubmed/27845389
http://dx.doi.org/10.1038/srep37052

Ejemplares similares