A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex

As a centerpiece of antigen processing, the ATP-binding cassette transporter associated with antigen processing (TAP) became a main target for viral immune evasion. The herpesviral ICP47 inhibits TAP function, thereby suppressing an adaptive immune response. Here, we report on a thermostable ICP47-T...

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Detalles Bibliográficos
Autores principales: Herbring, Valentina, Bäucker, Anja, Trowitzsch, Simon, Tampé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109273/
https://www.ncbi.nlm.nih.gov/pubmed/27845362
http://dx.doi.org/10.1038/srep36907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109273/
https://www.ncbi.nlm.nih.gov/pubmed/27845362
http://dx.doi.org/10.1038/srep36907

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