Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes

[Image: see text] MMV007564 is a novel antimalarial benzimidazolyl piperidine chemotype identified in cellular screens. To identify the genetic determinant of MMV007564 resistance, parasites were cultured in the presence of the compound to generate resistant lines. Whole genome sequencing revealed d...

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Detalles Bibliográficos
Autores principales: Magistrado, Pamela A., Corey, Victoria C., Lukens, Amanda K., LaMonte, Greg, Sasaki, Erika, Meister, Stephan, Wree, Melanie, Winzeler, Elizabeth, Wirth, Dyann F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109296/
https://www.ncbi.nlm.nih.gov/pubmed/27933786
http://dx.doi.org/10.1021/acsinfecdis.6b00025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109296/
https://www.ncbi.nlm.nih.gov/pubmed/27933786
http://dx.doi.org/10.1021/acsinfecdis.6b00025

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