Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell survival and catabolic enzyme production. Here, we analyse in vivo functions of Rela in embryonic limbs and adult articular cartilage, and find that Rela protects ch...

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Detalles Bibliográficos
Autores principales: Kobayashi, Hiroshi, Chang, Song Ho, Mori, Daisuke, Itoh, Shozo, Hirata, Makoto, Hosaka, Yoko, Taniguchi, Yuki, Okada, Keita, Mori, Yoshifumi, Yano, Fumiko, Chung, Ung-il, Akiyama, Haruhiko, Kawaguchi, Hiroshi, Tanaka, Sakae, Saito, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109547/
https://www.ncbi.nlm.nih.gov/pubmed/27830706
http://dx.doi.org/10.1038/ncomms13336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109547/
https://www.ncbi.nlm.nih.gov/pubmed/27830706
http://dx.doi.org/10.1038/ncomms13336

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