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Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma

BACKGROUND: Rhabdomyosarcoma (RMS), which can be classified as embryonal RMS (ERMS) and alveolar RMS (ARMS), represents the most frequent soft tissue sarcoma in the pediatric population; the latter shows greater aggressiveness and metastatic potential with respect to the former. Epigenetic alteratio...

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Detalles Bibliográficos
Autores principales: Tombolan, L., Poli, E., Martini, P., Zin, A., Millino, C., Pacchioni, B., Celegato, B., Bisogno, G., Romualdi, C., Rosolen, A., Lanfranchi, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109816/
https://www.ncbi.nlm.nih.gov/pubmed/27842508
http://dx.doi.org/10.1186/s12885-016-2936-3