pMHC affinity controls duration of CD8(+) T cell–DC interactions and imprints timing of effector differentiation versus expansion

During adaptive immune responses, CD8(+) T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protec...

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Detalles Bibliográficos
Autores principales: Ozga, Aleksandra J., Moalli, Federica, Abe, Jun, Swoger, Jim, Sharpe, James, Zehn, Dietmar, Kreutzfeldt, Mario, Merkler, Doron, Ripoll, Jorge, Stein, Jens V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110015/
https://www.ncbi.nlm.nih.gov/pubmed/27799622
http://dx.doi.org/10.1084/jem.20160206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110015/
https://www.ncbi.nlm.nih.gov/pubmed/27799622
http://dx.doi.org/10.1084/jem.20160206

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