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pMHC affinity controls duration of CD8(+) T cell–DC interactions and imprints timing of effector differentiation versus expansion
During adaptive immune responses, CD8(+) T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protec...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110015/ https://www.ncbi.nlm.nih.gov/pubmed/27799622 http://dx.doi.org/10.1084/jem.20160206 |