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Interferon lambda 4 expression is suppressed by the host during viral infection

Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, and IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unkno...

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Detalles Bibliográficos
Autores principales: Hong, MeeAe, Schwerk, Johannes, Lim, Chrissie, Kell, Alison, Jarret, Abigail, Pangallo, Joseph, Loo, Yueh-Ming, Liu, Shuanghu, Hagedorn, Curt H., Gale, Michael, Savan, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110018/
https://www.ncbi.nlm.nih.gov/pubmed/27799623
http://dx.doi.org/10.1084/jem.20160437