Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer’s disease (AD). Cell culture and animal studies showed that tau fibrils can undergo cell-to-cell transmission and seed aggregation of soluble tau, but this phenomenon was only robustly demonst...

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Detalles Bibliográficos
Autores principales: Guo, Jing L., Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J., Iba, Michiyo, McBride, Jennifer D., Trojanowski, John Q., Lee, Virginia M.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110027/
https://www.ncbi.nlm.nih.gov/pubmed/27810929
http://dx.doi.org/10.1084/jem.20160833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110027/
https://www.ncbi.nlm.nih.gov/pubmed/27810929
http://dx.doi.org/10.1084/jem.20160833

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