Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

PURPOSE: Oxidative stress has been linked to several ocular diseases, initiating an inflammatory response that increases tissue injury. The Nrf2 transcription factor regulates expression of antioxidant genes and is tightly regulated by Kelch-Like ECH-Associated Protein 1 (Keap-1). We evaluate the an...

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Detalles Bibliográficos
Autores principales: Ildefonso, Cristhian J., Jaime, Henrique, Brown, Emily E., Iwata, Ryo L., Ahmed, Chulbul M., Massengill, Michael T., Biswal, Manas R., Boye, Shannon E., Hauswirth, William W., Ash, John D., Li, Qiuhong, Lewin, Alfred S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110262/
https://www.ncbi.nlm.nih.gov/pubmed/26842755
http://dx.doi.org/10.1167/iovs.15-17703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110262/
https://www.ncbi.nlm.nih.gov/pubmed/26842755
http://dx.doi.org/10.1167/iovs.15-17703

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