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A Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture
PURPOSE: Primary open angle glaucoma–associated mutations in myocilin (MYOC) cause protein “nonsecretion,” rendering secreted MYOC difficult to detect using conventional techniques. This study focused on developing and using an assay that can quickly and easily detect mutant MYOC secretion. METHODS:...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110263/ https://www.ncbi.nlm.nih.gov/pubmed/27092720 http://dx.doi.org/10.1167/iovs.15-18789 |