Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-targeted STAT3 knockout (KO) mice and Angiotensin II (AN...

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Detalles Bibliográficos
Autores principales: Altara, Raffaele, Harmancey, Romain, Didion, Sean P., Booz, George W., Zouein, Fouad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110511/
https://www.ncbi.nlm.nih.gov/pubmed/27899891
http://dx.doi.org/10.3389/fphar.2016.00436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110511/
https://www.ncbi.nlm.nih.gov/pubmed/27899891
http://dx.doi.org/10.3389/fphar.2016.00436

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