Cargando…

ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to detoxify 4-hydroxy-2-nonenal, a reactive aldehyde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Guodong, Deshpande, Mandar, Thandavarayan, Rajarajan A., Palaniyandi, Suresh Selvaraj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110883/ https://www.ncbi.nlm.nih.gov/pubmed/27882330 http://dx.doi.org/10.1155/2016/1390861

Ejemplares similares

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography
por: Pan, Guodong, et al.
Publicado: (2018)

Correction: Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 2*2) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography
por: Pan, Guodong, et al.
Publicado: (2018)

Cardiac Mitochondrial Respiratory Dysfunction and Tissue Damage in Chronic Hyperglycemia Correlate with Reduced Aldehyde Dehydrogenase-2 Activity
por: Mali, Vishal R., et al.
Publicado: (2016)

Diabetic Aldehyde Dehydrogenase 2 Mutant (ALDH2*2) Mice Are More Susceptible to Cardiac Ischemic‐Reperfusion Injury Due to 4‐Hydroxy‐2‐Nonenal Induced Coronary Endothelial Cell Damage
por: Pan, Guodong, et al.
Publicado: (2021)

Aldehyde Dehydrogenase 2 Activator Augments the Beneficial Effects of Empagliflozin in Mice with Diabetes-Associated HFpEF
por: Pan, Guodong, et al.
Publicado: (2022)

3′UTR shortening of profibrotic genes and reversibility of fibrosis in patients with end‐stage right ventricular failure
por: Neupane, Rahul, et al.
Publicado: (2022)

SARS–CoV-2 Mediated Hyperferritinemia and Cardiac Arrest: Preliminary Insights
por: VasanthiDharmalingam, Prakash, et al.
Publicado: (2021)

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes
por: Suresh Babu, Sahana, et al.
Publicado: (2016)

Sca-1+ Cells from Fetal Heart with High Aldehyde Dehydrogenase Activity Exhibit Enhanced Gene Expression for Self-Renewal, Proliferation, and Survival
por: Dey, Devaveena, et al.
Publicado: (2015)

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice
por: Karuppagounder, Vengadeshprabhu, et al.
Publicado: (2016)

Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats
por: Arumugam, Somasundaram, et al.
Publicado: (2012)

Rutin alleviates cardiomyocyte injury induced by high glucose through inhibiting apoptosis and endoplasmic reticulum stress
por: Wang, Jing, et al.
Publicado: (2021)

Small Engine, Big Power: MicroRNAs as Regulators of Cardiac Diseases and Regeneration
por: Joladarashi, Darukeshwara, et al.
Publicado: (2014)

Tissue-specific role and associated downstream signaling pathways of adiponectin
por: Roy, Bipradas, et al.
Publicado: (2021)

Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells
por: Mu, Xiaodong, et al.
Publicado: (2013)

Roles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injury
por: Jiang, Shi-Jun
Publicado: (2022)

Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2
por: Roy, Bipradas, et al.
Publicado: (2022)

Activation of TGR5 Partially Alleviates High Glucose-Induced Cardiomyocyte Injury by Inhibition of Inflammatory Responses and Oxidative Stress
por: Deng, Li, et al.
Publicado: (2019)

Effect of ALDH2 on High Glucose-Induced Cardiac Fibroblast Oxidative Stress, Apoptosis, and Fibrosis
por: Gu, Xiaoyu, et al.
Publicado: (2017)

PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses
por: Palaniyandi, Suresh Selvaraj, et al.
Publicado: (2011)

ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation
por: Cao, Ruiping, et al.
Publicado: (2019)

Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling
por: Thandavarayan, Rajarajan A., et al.
Publicado: (2015)

Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy
por: Arumugam, Somasundaram, et al.
Publicado: (2012)

Antioxidant Formulae, Shengmai San, and LingGuiZhuGanTang, Prevent MPTP Induced Brain Dysfunction and Oxidative Damage in Mice
por: Giridharan, Vijayasree Vayalanellore, et al.
Publicado: (2015)

The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
por: Zhang, Hong, et al.
Publicado: (2021)

Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases
por: Jayaraman, Selvaraj, et al.
Publicado: (2021)

Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids
por: Gao, Yanhang, et al.
Publicado: (2019)

Corrigendum to “ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation”
por: Cao, Ruiping, et al.
Publicado: (2021)

Inhibition of miR-186-5p contributes to high glucose-induced injury in AC16 cardiomyocytes
por: Jiang, Jiamei, et al.
Publicado: (2018)

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
por: Karuppagounder, Vengadeshprabhu, et al.
Publicado: (2018)

Inhibition of ALDH2 by O-GlcNAcylation contributes to the hyperglycemic exacerbation of myocardial ischemia/reperfusion injury
por: Liu, Baoshan, et al.
Publicado: (2016)

Emerging Mechanisms of Pulmonary Vasoconstriction in SARS-CoV-2-Induced Acute Respiratory Distress Syndrome (ARDS) and Potential Therapeutic Targets
por: Karmouty-Quintana, Harry, et al.
Publicado: (2020)

ALDH1A3 Accelerates Pancreatic Cancer Metastasis by Promoting Glucose Metabolism
por: Nie, Shuang, et al.
Publicado: (2020)

Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression
por: Giridharan, Vijayasree V., et al.
Publicado: (2015)

Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways
por: Wang, Yu, et al.
Publicado: (2016)

Tanshinone I Inhibits Oxidative Stress–Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling
por: Wu, Yu-Ting, et al.
Publicado: (2021)

Mangiferin Enhanced Autophagy via Inhibiting mTORC1 Pathway to Prevent High Glucose-Induced Cardiomyocyte Injury
por: Hou, Jun, et al.
Publicado: (2018)

An In Vitro Platform to Study Reversible Endothelial-to-Mesenchymal Transition
por: Krishnamoorthi, Muthu Kumar, et al.
Publicado: (2022)

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes
por: Mattera, Rosanna, et al.
Publicado: (2017)

Update of ALDH as a Potential Biomarker and Therapeutic Target for AML
por: Yang, Xiangchou, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_m2v0i8ldglj7fjpuhasb827p29