Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection

The human interferon-inducible protein IFI16 is an important antiviral factor that binds nuclear viral DNA and promotes antiviral responses. Here, we define IFI16 dynamics in space and time and its distinct functions from the DNA sensor cyclic dinucleotide GMP-AMP synthase (cGAS). Live-cell imaging...

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Detalles Bibliográficos
Autores principales: Diner, Benjamin A., Lum, Krystal K., Toettcher, Jared E., Cristea, Ileana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111403/
https://www.ncbi.nlm.nih.gov/pubmed/27935834
http://dx.doi.org/10.1128/mBio.01553-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111403/
https://www.ncbi.nlm.nih.gov/pubmed/27935834
http://dx.doi.org/10.1128/mBio.01553-16

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