Conformational quiescence of ADAMTS‐13 prevents proteolytic promiscuity

ESSENTIALS: Recently, ADAMTS‐13 has been shown to undergo substrate induced conformation activation. Conformational quiescence of ADAMTS‐13 may serve to prevent off‐target proteolysis in plasma. Conformationally active ADAMTS‐13 variants are capable of proteolysing the Aα chain of fibrinogen. This s...

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Detalles Bibliográficos
Autores principales: South, K., Freitas, M. O., Lane, D. A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
COAGULATION
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111603/
https://www.ncbi.nlm.nih.gov/pubmed/27514025
http://dx.doi.org/10.1111/jth.13445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111603/
https://www.ncbi.nlm.nih.gov/pubmed/27514025
http://dx.doi.org/10.1111/jth.13445

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