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Conformational quiescence of ADAMTS‐13 prevents proteolytic promiscuity
ESSENTIALS: Recently, ADAMTS‐13 has been shown to undergo substrate induced conformation activation. Conformational quiescence of ADAMTS‐13 may serve to prevent off‐target proteolysis in plasma. Conformationally active ADAMTS‐13 variants are capable of proteolysing the Aα chain of fibrinogen. This s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111603/ https://www.ncbi.nlm.nih.gov/pubmed/27514025 http://dx.doi.org/10.1111/jth.13445 |