Damage‐inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter

Wild‐type TP53 exons 5–8 contain CpG dinucleotides that are prone to methylation‐dependent mutation during carcinogenesis, but the regulatory effects of methylation affecting these CpG sites are unclear. To clarify this, we first assessed site‐specific TP53 CpG methylation in normal and transformed...

Descripción completa

Detalles Bibliográficos
Autores principales: Blackburn, James, Roden, Daniel L., Ng, Robert, Wu, Jianmin, Bosman, Alexis, Epstein, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111752/
https://www.ncbi.nlm.nih.gov/pubmed/26676339
http://dx.doi.org/10.1002/mc.22441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111752/
https://www.ncbi.nlm.nih.gov/pubmed/26676339
http://dx.doi.org/10.1002/mc.22441

Ejemplares similares