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Synthetic Nucleosomes Reveal that GlcNAcylation Modulates Direct Interaction with the FACT Complex

Transcriptional regulation can be established by various post‐translational modifications (PTMs) on histone proteins in the nucleosome and by nucleobase modifications on chromosomal DNA. Functional consequences of histone O‐GlcNAcylation (O‐GlcNAc=O‐linked β‐N‐acetylglucosamine) are largely unexplor...

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Detalles Bibliográficos
Autores principales: Raj, Ritu, Lercher, Lukas, Mohammed, Shabaz, Davis, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111754/
https://www.ncbi.nlm.nih.gov/pubmed/27272618
http://dx.doi.org/10.1002/anie.201603106