XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells

Previous work has shown that the three‐dimensional (3D) nuclear organization of telomeres is altered in cancer cells and the degree of alterations coincides with aggressiveness of disease. Nuclear pores are essential for spatial genome organization and gene regulation and XPO1 (exportin 1/CRM1) is t...

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Detalles Bibliográficos
Autores principales: Taylor‐Kashton, Cheryl, Lichtensztejn, Daniel, Baloglu, Erkan, Senapedis, William, Shacham, Sharon, Kauffman, Michael G., Kotb, Rami, Mai, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111786/
https://www.ncbi.nlm.nih.gov/pubmed/26991404
http://dx.doi.org/10.1002/jcp.25378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111786/
https://www.ncbi.nlm.nih.gov/pubmed/26991404
http://dx.doi.org/10.1002/jcp.25378

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