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Optimization of phenylhydrazine induced hyperbilirubinemia in experimental rabbit
Induction of hyperbilirubinemia in experimental rabbits by phenylhydrazine was optimized in terms of dose, dose interval and number of doses using response surface methodology. Central Composite Design was employed using five levels for each of the three input variables. Degree of hyperbilirubinemia...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111839/ https://www.ncbi.nlm.nih.gov/pubmed/27210076 http://dx.doi.org/10.1538/expanim.16-0011 |