NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 mus...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Dalei, Su, Xiaoyu, Potluri, Nalini, Kim, Youngchang, Rastinejad, Fraydoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111884/
https://www.ncbi.nlm.nih.gov/pubmed/27782878
http://dx.doi.org/10.7554/eLife.18790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111884/
https://www.ncbi.nlm.nih.gov/pubmed/27782878
http://dx.doi.org/10.7554/eLife.18790

Ejemplares similares