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NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 mus...

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Detalles Bibliográficos
Autores principales:	Wu, Dalei, Su, Xiaoyu, Potluri, Nalini, Kim, Youngchang, Rastinejad, Fraydoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111884/ https://www.ncbi.nlm.nih.gov/pubmed/27782878 http://dx.doi.org/10.7554/eLife.18790

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