Novel Podophyllotoxin Derivatives as Partial PPARγ Agonists and their Effects on Insulin Resistance and Type 2 Diabetes

Peroxisome proliferator-activated receptor γ (PPARγ) is recognized as a key regulator of insulin resistance. In this study, we searched for novel PPARγ agonists in a library of structurally diverse organic compounds and determined that podophyllotoxin exhibits partial agonist activity toward PPARγ....

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Detalles Bibliográficos
Autores principales: Zhang, Xiangming, Liu, Huijuan, Sun, Bo, Sun, Yan, Zhong, Weilong, Liu, Yanrong, Chen, Shuang, Ling, Honglei, Zhou, Lei, Jing, Xiangyan, Qin, Yuan, Xiao, Ting, Sun, Tao, Zhou, Honggang, Yang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112511/
https://www.ncbi.nlm.nih.gov/pubmed/27853282
http://dx.doi.org/10.1038/srep37323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112511/
https://www.ncbi.nlm.nih.gov/pubmed/27853282
http://dx.doi.org/10.1038/srep37323

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