Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching

Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine deaminase (AID). Through a genome-wide RNAi screen, we identified Kin17 as a gene potentially involved in the maintenance of CS...

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Detalles Bibliográficos
Autores principales: Le, Michael X., Haddad, Dania, Ling, Alexanda K., Li, Conglei, So, Clare C., Chopra, Amit, Hu, Rui, Angulo, Jaime F., Moffat, Jason, Martin, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112545/
https://www.ncbi.nlm.nih.gov/pubmed/27853268
http://dx.doi.org/10.1038/srep37215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112545/
https://www.ncbi.nlm.nih.gov/pubmed/27853268
http://dx.doi.org/10.1038/srep37215

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