Cargando…

Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching

Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine deaminase (AID). Through a genome-wide RNAi screen, we identified Kin17 as a gene potentially involved in the maintenance of CS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Le, Michael X., Haddad, Dania, Ling, Alexanda K., Li, Conglei, So, Clare C., Chopra, Amit, Hu, Rui, Angulo, Jaime F., Moffat, Jason, Martin, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112545/ https://www.ncbi.nlm.nih.gov/pubmed/27853268 http://dx.doi.org/10.1038/srep37215

Ejemplares similares

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
por: Li, Conglei, et al.
Publicado: (2018)

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein
por: Gaspar, Vanessa Pinatto, et al.
Publicado: (2021)

Phosphorylation: The Molecular Switch of Double-Strand Break Repair
por: Summers, K. C., et al.
Publicado: (2011)

Genome plasticity is governed by double strand break DNA repair in Streptomyces
por: Hoff, Grégory, et al.
Publicado: (2018)

Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination
por: Bregenhorn, Stephanie, et al.
Publicado: (2016)

The kin17 Protein in Murine Melanoma Cells
por: Ramos, Anelise C., et al.
Publicado: (2015)

The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination
por: Chahwan, Richard, et al.
Publicado: (2012)

Fixing DNA breaks during class switch recombination
por: Jolly, Christopher J., et al.
Publicado: (2008)

Roles and regulatory mechanisms of KIN17 in cancers (Review)
por: Huang, Xueran, et al.
Publicado: (2023)

Analysis of the association between KIN17 expression and the clinical features/prognosis of epithelial ovarian cancer, and the effects of KIN17 in SKOV3 cells
por: Chen, Junyu, et al.
Publicado: (2021)

53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
por: Sundaravinayagam, Devakumar, et al.
Publicado: (2019)

Up-Regulation of Kin17 Is Essential for Proliferation of Breast Cancer
por: Zeng, Tao, et al.
Publicado: (2011)

Kin and Non-Kin Connected Plants Benefit More Than Disconnected Kin and Non-Kin Plants under Nutrient-Competitive Environments
por: Sher, Jan, et al.
Publicado: (2023)

Direct visualization of a molecular handshake that governs kin recognition and tissue formation in myxobacteria
por: Cao, Pengbo, et al.
Publicado: (2019)

Kith and kin
por: Fothergill, Jessie, 1851-1891
Publicado: (1881)

Neural pathways of olfactory kin imprinting and kin recognition in zebrafish
por: Gerlach, Gabriele, et al.
Publicado: (2021)

Expression of Kin17 promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo
por: KOU, WEI-ZHENG, et al.
Publicado: (2014)

Upregulation of KIN17 is associated with non-small cell lung cancer invasiveness
por: Zhang, Yuzhao, et al.
Publicado: (2017)

Aggression and spatial positioning of kin and non-kin fish in social groups
por: Bose, Aneesh P H, et al.
Publicado: (2023)

Proteins pinpoint double strand breaks
por: Cox, Michael M
Publicado: (2013)

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
por: Guikema, Jeroen E.J., et al.
Publicado: (2007)

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
por: Guikema, Jeroen E.J., et al.
Publicado: (2007)

The Function of AID in Somatic Mutation and Class Switch Recombination: Upstream or Downstream of DNA Breaks
por: Chua, Katrin F., et al.
Publicado: (2002)

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
por: Dong, Junchao, et al.
Publicado: (2015)

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination
por: Nicolas, Laura, et al.
Publicado: (2018)

ZmRAD17 Is Required for Accurate Double-Strand Break Repair During Maize Male Meiosis
por: Zhang, Ting, et al.
Publicado: (2021)

Deciphering the functional mechanism of zinc ions of PARP1 binding with single strand breaks and double strand breaks
por: Sun, Shuya, et al.
Publicado: (2022)

"Tene 'kin báaxtik, kin tzikbatik yetel kin dzíibtik in a'almaj t'aano{thorn}ob" ="Juego, platico y escribo mis derechos" /
Publicado: (2002)

On genomics, kin, and privacy
por: Telenti, Amalio, et al.
Publicado: (2014)

The Marriage of near Kin
Publicado: (1876)

Kin selection spreads
por: Higham, James P
Publicado: (2022)

An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells
por: Sousa, Mirta M. L., et al.
Publicado: (2013)

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
por: Eccles, Laura J., et al.
Publicado: (2010)

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
por: Abdou, Ismail, et al.
Publicado: (2015)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination
por: Santos, Joana M., et al.
Publicado: (2018)

DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
por: Wu, Xiaoming, et al.
Publicado: (2007)

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice
por: Thivolle, Alix, et al.
Publicado: (2021)

Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair
por: Johnson, Rebecca, et al.
Publicado: (2007)

PARP retains Ku at double-strand breaks
por: Short, Ben
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9s5rvvcq66ivhr994o32p113ef