Activation of FXR protects against renal fibrosis via suppressing Smad3 expression

Renal fibrosis is the common pathway of most chronic kidney disease progression to end-stage renal failure. The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcription factor, plays an important role in protecting against fibrosis. The TGFβ-Smad signaling has a central role...

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Detalles Bibliográficos
Autores principales: Zhao, Kai, He, Jialin, Zhang, Yan, Xu, Zhizhen, Xiong, Haojun, Gong, Rujun, Li, Song, Chen, Shan, He, Fengtian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112546/
https://www.ncbi.nlm.nih.gov/pubmed/27853248
http://dx.doi.org/10.1038/srep37234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112546/
https://www.ncbi.nlm.nih.gov/pubmed/27853248
http://dx.doi.org/10.1038/srep37234

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