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Activation of FXR protects against renal fibrosis via suppressing Smad3 expression
Renal fibrosis is the common pathway of most chronic kidney disease progression to end-stage renal failure. The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcription factor, plays an important role in protecting against fibrosis. The TGFβ-Smad signaling has a central role...
Autores principales: | Zhao, Kai, He, Jialin, Zhang, Yan, Xu, Zhizhen, Xiong, Haojun, Gong, Rujun, Li, Song, Chen, Shan, He, Fengtian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112546/ https://www.ncbi.nlm.nih.gov/pubmed/27853248 http://dx.doi.org/10.1038/srep37234 |
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