Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target

The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to this aberrant microenvironmental factor remains to be fully characterised. The aim here was to address the hypothesi...

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Detalles Bibliográficos
Autores principales: Gilbert, Hamish T. J., Hodson, Nathan, Baird, Pauline, Richardson, Stephen M., Hoyland, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112591/
https://www.ncbi.nlm.nih.gov/pubmed/27853274
http://dx.doi.org/10.1038/srep37360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112591/
https://www.ncbi.nlm.nih.gov/pubmed/27853274
http://dx.doi.org/10.1038/srep37360

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