Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets

We have previously demonstrated that islet depolarization with 70 mM KCl opens Cx36 hemichannels and allows diffusion of small metabolites and cofactors through the β-cell plasma membrane. We have investigated in this islet “permeabilized” model whether glycolytic and citric acid cycle intermediates...

Descripción completa

Detalles Bibliográficos
Autores principales: Pizarro-Delgado, Javier, Deeney, Jude T., Corkey, Barbara E., Tamarit-Rodriguez, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112877/
https://www.ncbi.nlm.nih.gov/pubmed/27851770
http://dx.doi.org/10.1371/journal.pone.0166111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112877/
https://www.ncbi.nlm.nih.gov/pubmed/27851770
http://dx.doi.org/10.1371/journal.pone.0166111

Ejemplares similares